During exertional heat stroke, splanchnic blood flow is redirected to the skin for thermoregulation. The resulting intestinal ischemia compromises the sodium-dependent transport pathway that every existing oral rehydration solution relies on.
Exertional heat illness is the leading preventable cause of death during military training.
Severe redistribution of blood flow during heat stroke creates critical intestinal ischemia within minutes.
Current oral rehydration solutions were not developed for — and have not been tested under — intestinal ischemia conditions.
Mimetic Gel targets an independent intestinal absorption mechanism that operates through a distinct electrochemical driving force — not the sodium-dependent pathway that fails under ischemia.
Delivers a specific dipeptide substrate through an independent, proton-coupled absorption pathway that does not depend on the sodium gradient or cellular ATP at the transport step.
A non-Newtonian hydrocolloid matrix engineered for controlled gastric release — eliminating the mixing errors, hygroscopic degradation, and dosing variability inherent in powdered ORS.
Beyond hydration, the formulation is designed to support intestinal epithelial barrier integrity through a specific molecular cascade — addressing the gut permeability crisis that drives systemic complications in heat stroke.
In prolonged field care, mass casualty, and austere environments, IV access is often rate-limiting or unavailable. Mimetic Gel provides an oral-enteral path to fluid resuscitation without medical training or sterile equipment.
Designed first for military heat casualties, with dual-use potential across civilian emergency medicine, occupational health, and athletics.
Prolonged field care, combat medic kits, pre-hospital heat casualty management, and mass casualty logistics reduction.
First-responder administered enteral hydration for heat emergencies where IV access is delayed or unavailable.
Endurance athletes, wildland firefighters, agricultural workers, and industrial heat exposure environments.
We're pursuing federal R&D funding and seeking partners in military medicine, GI physiology, and defense health research.
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